Stage of research
Diagnostic and prognostic research · Multicentre study
Mehmet Çolakoğlu website · Patient information ·
What did the 2025 study examine?
In 571 men, a gene panel provided a diagnosis in 6.1%. Associations with sperm retrieval were identified for some genes. This supports individualised decisions, not gene therapy; predictive evidence remains limited for many genes. [1]
What might extended panels change?
When production problems remain unexplained after standard investigations, a closer look at genes involved in sperm development may be considered. Understanding a genetic cause can clarify which process is affected and the expectations discussed before surgery. The purpose is better diagnosis and decisions: identifying a gene does not mean a treatment to repair it is available. [1]
Why do results need specialist interpretation?
Not every genetic variant causes disease. A report should explain the significance of a finding and the strength of evidence. An uninformative result also cannot exclude every genetic cause. Implications for relatives and future children belong in genetic counselling. Before another panel, ask about earlier test coverage and whether a result could change the Micro-TESE decision.
Make the Micro-TESE discussion more useful
Bring earlier genetic reports, operative notes and pathology results together. Ask whether another test might change the decision, when it should be performed and how the couple’s plan will be managed while waiting. In an IVF consultation with Prof. Dr. Mehmet Çolakoğlu, discuss coordination with urology and genetics specialists.
Frequently asked questions
Is 6.1% a sperm retrieval or pregnancy rate?
No. It is the proportion receiving an explanatory genetic diagnosis using that study’s panel. It is distinct from retrieval, pregnancy and live birth.
Does everyone need an extended gene panel?
Discuss this individually. First establish what question testing would answer and how a result could contribute to your decisions.
Sources
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